New Constraints on the Timing and Pattern of Deglaciation in the Húnaflói Bay Region of Northwest Iceland Using Cosmogenic 36CA Dating and Geomorphic Mapping

Understanding the evolution and timing of changes in ice sheet geometry and extent in Iceland during the Last Glacial Maximum (LGM) and subsequent deglaciation continues to stimulate much active research. Though many previous studies have advanced our knowledge of Icelandic ice sheet history preserved in marine and terrestrial settings (e.g., Andrews et al., 2000; Norðdahl et al., 2008), the timing of ice margin retreat remains largely unknown in several key regions. Recently published 36Cl surface exposure ages of bedrock surfaces and moraines in the West Fjords (Brynjólfsson et al., 2015) contribute important progress in establishing more precise age control of ice recession in northwest Iceland. In another recent study, the spatial pattern and style of deglaciation in northern Iceland have been revealed through geomorphic mapping and GIS analyses of glacial landforms (Principato et al., 2016). Additional insight comes from updated numerical modeling reconstructions, which now provide a series of glaciologically plausible Icelandic ice sheet configurations from the LGM through the last deglaciation (Patton et al., 2017). However, the optimization of ice sheet model simulations relies on critical comparisons with the available empirical record of glacial-geologic evidence and chronological control, which remains relatively limited and sparsely distributed throughout Iceland. Our investigation is motivated by the need for more accurate constraints on the deglacial history in northern Iceland, where dated terrestrial records of ice margin retreat are particularly scarce. (excerpt

A loess–paleosol record of climate and glacial history over the past two glacial–interglacial cycles (~150 ka), southern Jackson Hole, Wyoming

Loess accumulated on a Bull Lake outwash terrace of Marine Oxygen Isotope Stage 6 (MIS 6) age in southern Jackson Hole, Wyoming. The 9 m section displays eight intervals of loess deposition (Loess 1 to Loess 8, oldest), each followed by soil development. Our age-depth model is constrained by thermoluminescence, meteoric 10Be accumulation in soils, and cosmogenic 10Be surface exposure ages. We use particle size, geochemical, mineral-magnetic, and clay mineralogical data to interpret loess sources and pedogenesis. Deposition of MIS 6 loess was followed by a tripartite soil/thin loess complex (Soils 8, 7, and 6) apparently re!ecting the large climatic oscillations of MIS 5. Soil 8 (MIS 5e) shows the strongest development. Loess 5 accumulated during a glacial interval (~76–69 ka; MIS 4) followed by soil development under conditions wetter and probably colder than present. Deposition of thick Loess 3 (~43–51 ka, MIS 3) was followed by soil development comparable with that observed in Soil 1. Loess 1 (MIS 2) accumulated during the Pinedale glaciation and was followed by development of Soil 1 under a semiarid climate. This record of alternating loess deposition and soil development is compatible with the history of Yellowstone vegetation and the glacial !our record from the Sierra Nevada

Pinedale Glacial History of the Upper Arkansas River Valley: New Moraine Chronologies, Modeling Results and Geologic Mapping

This field trip guidebook chapter outlines the glacial history of the upper Arkansas River valley, Colorado, and builds on a previous GSA field trip to the same area in 2010. The following will be presented: (1) new cosmogenic 10Be exposure ages of moraine boulders from the Pinedale and Bull Lake glaciations (Marine Isotope Stages 2 and 6, respectively) located adjacent to the Twin Lakes Reservoir, (2) numerical modeling of glaciers during the Pinedale glaciation in major tributaries draining into the upper Arkansas River, (3) discharge estimates for glacial-lake outburst floods in the upper Arkansas River valley, and (4) 10Be ages on flood boulders deposited downvalley from the moraine sequences. This research was stimulated by a new geologic map of the Granite 7.5’ quadrangle, in which the mapping of surficial deposits was revised based in part on the interpretation of newly acquired LiDAR data and field investigations. The new 10Be ages of the Pinedale terminal moraine at Twin Lakes average 21.8 ± 0.7 ka (n=14), which adds to nearby Pinedale terminal moraine ages of 23.6 ± 1.4 ka (n=5), 20.5 ± 0.2 ka (n=3) and 16.6 ± 1.0 ka, and downvalley outburst flood terraces that date to 20.9 ± 0.9 ka (n=4) and 19.0 ± 0.6 ka (n=4). This growing chronology leads to improved understanding of the controls and timing of glaciation in the western U.S., the modeling of glacial-lake outburst flooding, and the reconstruction of paleo-temperature through glacier modeling

Rapid early Holocene deglaciation of the Laurentide ice sheet

Author Posting. © Nature Publishing Group, 2008. This is the author's version of the work. It is posted here by permission of Nature Publishing Group for personal use, not for redistribution. The definitive version was published in Nature Geoscience 1 (2008): 620-624, doi:10.1038/ngeo285.The early Holocene deglaciation of the Laurentide Ice Sheet (LIS) is the most recent and best constrained disappearance of a large Northern Hemisphere ice sheet. Its demise is a natural experiment for assessing rates of ice sheet decay and attendant contributions to sea level rise. Here we demonstrate with terrestrial and marine records that the final LIS demise occurred in two stages of rapid melting from ~9.0- 8.5 and 7.6-6.8 kyr BP with the LIS contributing ~1.3 and 0.7 cm yr-1 to sea level rise, respectively. Simulations using a fully coupled atmosphere-ocean general circulation model suggest that increased ablation from enhanced early Holocene boreal summer insolation may have been the predominant cause of the LIS contributions to sea level rise. Although the boreal summer surface radiative forcing of early Holocene LIS retreat is twice that of projections for 2100 C.E. greenhouse gas radiative forcing, the associated summer surface air temperature increase is the same. The geologic evidence for rapid LIS retreat under a comparable forcing provides a prehistoric precedent for a possible large negative mass balance response of the Greenland Ice Sheet by the end of the coming century.This research was funded by National Science Foundation grants ATM-05-01351 & ATM-05-01241 to D.W.O. & G.A.S., start-up funds from the University of Wisconsin-Madison and a Woods Hole Oceanographic Institution Postdoctoral Scholarship to A.E.C., and the Woods Hole Oceanographic Institution's Ocean and Climate Change Institute (D.W.O. & R.E.C.)

Cosmogenic Ages Indicate No MIS 2 Refugia in the Alexander Archipelago, Alaska

The late-Pleistocene history of the coastal Cordilleran Ice Sheet remains relatively unstudied compared to chronologies of the Laurentide Ice Sheet. Yet accurate reconstructions of Cordilleran Ice Sheet extent and the timing of ice retreat along the Pacific Coast are essential for paleoclimate modeling, assessing meltwater contribution to the North Pacific, and determining the availability of ice-free land along the coastal Cordilleran Ice Sheet margin for human migration from Beringia into the rest of the Americas. To improve the chronology of Cordilleran Ice Sheet history in the Alexander Archipelago, Alaska, we applied 10Be and 36Cl dating to boulders and glacially sculpted bedrock in areas previously hypothesized to have remained ice-free throughout the local Last Glacial Maximum (LLGM; 20–17 ka). Results indicate that these sites, and more generally the coastal northern Alexander Archipelago, became ice-free by 15.1 ± 0.9 ka (n = 12 boulders; 1 SD). We also provide further age constraints on deglaciation along the southern Alexander Archipelago and combine our new ages with data from two previous studies. We determine that ice retreatedfrom the outer coast of the southern Alexander Archipelago at 16.3 ± 0.8 ka (n = 14 boulders; 1 SD). These results collectively indicate that areas above modern sea level that were previously mapped as glacial refugia were covered by ice during the LLGM until between ∼ 16.3 and 15.1 ka. As no evidence was found for ice-free land during the LLGM, our results suggest that previous ice-sheet reconstructions underestimate the regional maximum Cordilleran Ice Sheet extent, and that all ice likely terminated on the continental shelf. Future work should investigate whether presently submerged areas of the continental shelf were ice-free

Laurentide ice-sheet instability during the last deglaciation

Changes in the amount of summer incoming solar radiation (insolation) reaching the Northern Hemisphere are the underlying pacemaker of glacial cycles. However, not all rises in boreal summer insolation over the past 800,000 years resulted in deglaciation to present-day ice volumes, suggesting that there may be a climatic threshold for the disappearance of land-based ice. Here we assess the surface mass balance stability of the Laurentide ice sheet—the largest glacial ice mass in the Northern Hemisphere—during the last deglaciation (24,000 to 9,000 years ago). We run a surface energy balance model with climate data from simulations with a fully coupled atmosphere–ocean general circulation model for key time slices during the last deglaciation. We find that the surface mass balance of the Laurentide ice sheet was positive throughout much of the deglaciation, and suggest that dynamic discharge was mainly responsible for mass loss during this time. Total surface mass balance became negative only in the early Holocene, indicating the transition to a new state where ice loss occurred primarily by surface ablation. We conclude that the Laurentide ice sheet remained a viable ice sheet before the Holocene and began to fully deglaciate only once summer temperatures and radiative forcing over the ice sheet increased by 6–7 °C and 16–20 W m⁻², respectively, relative to full glacial conditions

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

Persistent latent reservoir of replication-competent proviruses in memory CD4 T cells is a major obstacle to curing HIV infection. Pharmacological activation of HIV expression in latently infected cells is being explored as one of the strategies to deplete the latent HIV reservoir. In this study, we characterized the ability of romidepsin (RMD), a histone deacetylase inhibitor approved for the treatment of T-cell lymphomas, to activate the expression of latent HIV. In an in vitro T-cell model of HIV latency, RMD was the most potent inducer of HIV (EC50 = 4.5 nM) compared with vorinostat (VOR; EC50 = 3,950 nM) and other histone deacetylase (HDAC) inhibitors in clinical development including panobinostat (PNB; EC50 = 10 nM). The HIV induction potencies of RMD, VOR, and PNB paralleled their inhibitory activities against multiple human HDAC isoenzymes. In both resting and memory CD4 T cells isolated from HIV-infected patients on suppressive combination antiretroviral therapy (cART), a 4-hour exposure to 40 nM RMD induced a mean 6-fold increase in intracellular HIV RNA levels, whereas a 24-hour treatment with 1 μM VOR resulted in 2- to 3-fold increases. RMD-induced intracellular HIV RNA expression persisted for 48 hours and correlated with sustained inhibition of cell-associated HDAC activity. By comparison, the induction of HIV RNA by VOR and PNB was transient and diminished after 24 hours. RMD also increased levels of extracellular HIV RNA and virions from both memory and resting CD4 T-cell cultures. The activation of HIV expression was observed at RMD concentrations below the drug plasma levels achieved by doses used in patients treated for T-cell lymphomas. In conclusion, RMD induces HIV expression ex vivo at concentrations that can be achieved clinically, indicating that the drug may reactivate latent HIV in patients on suppressive cART

Chlorine-36 concentration data for surface exposure age calculations from the Adirondacks, New York, USA

Properties and analytical data for samples collected for chlorine-36 surface exposure ages in the Adirondack Mountains of New York, USA. Also includes the major and trace element chemistry for the samples necessary for exposure age calculations